Description
Product Characteristics: Synonyms: MTG16, MTGR2, ZMYND4
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes(PubMed: 12559562, PubMed: 15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner(PubMed: 23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A, interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway(PubMed: 25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A(PubMed: 23840896, PubMed: 25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes(By similarity). Plays a role in granulocyte differentiation(PubMed: 15231665). Isoform 2 functions as an A-kinase-anchoring protein(PubMed: 11823486).
Target Information: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\,21)(q24\,q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]